Friedreich's Ataxia Genetics

Friedreich’s ataxia is a genetic disorder that gradually causes increasing damage to the nervous system. Symptoms vary depending on the stage and severity of the disease but range from difficulty with speech and coordination through to curvature of the spine and cardiac problems.

The condition was named after Nicholaus Friedreich who first described the condition in 1863. Although Friedreich established that there was a familial element to the condition, he was unable to identify the exact mode of inheritance. Since then, researchers have learned that Friedreich’s ataxia is inherited in an autosomal recessive manner.

Autosomal recessive inheritance

Autosomal recessive inheritance means that two defective genes, one from either parent, need to be inherited by offspring if they are to develop the disease. Every individual carries two copies of all their genes, with one copy inherited from each parent. If both the mother and father are carriers of this disease, each then possess one defective gene and one normal gene. The likelihood of each parent passing on the defected gene to their child is therefore one in two, meaning their child has a 50% chance of inheriting one defected gene and becoming a carrier. The child also has a one in four (25%) chance of inheriting the defected gene from both parents, in which case they will go on to develop the disease themselves. If the child inherits only the unaffected copy of the gene from each of their parents, they will not develop the disease and neither will they be a carrier. Again, the chance of this occurring is one in four or 25%.

Mutations

Friedreich’s ataxia is caused by mutation in the FXN gene. This gene, which is present on chromosome 9, codes for the protein frataxin. Frataxin is an iron-binding protein required for the normal function of mitochondria, in particular for removing iron from the cytoplasm surrounding the mitochondria. When FXN mutation causes this protein to be deficient or absent, mitochondrial iron overload occurs which causes oxidative damage to cells. The nerve and muscle cells are the primary cells affected.

In Friedreich’s ataxia, the mutation is an expansion in the repeat of the trinucleotide GAA in the first intron of the FXN gene. A person with Friedreich’s ataxia has over 100 of these repeats, which can reach almost 2,000 in number. This compares with only 40 GAA repeats in healthy individuals. The higher the number of GAA repeats, the less the frataxin protein is expressed.