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Treatment for those with lissencephaly is symptomatic and depends on the severity and locations of the brain malformations.
Supportive care may be needed to help with comfort and nursing needs.
Seizures may be controlled with medication and hydrocephalus may require shunting. If feeding becomes difficult, a gastrostomy tube may be considered.
The prognosis for children with lissencephaly varies depending on the degree of brain malformation.
Many individuals show no significant development beyond a 3- to 5-month-old level. Some may have near-normal development and intelligence.
With modern medications and care, some children live into their teens.
Respiratory problems are the most common causes of death.