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The science of pharmacoepidemiology can answer a range of questions regarding how, why, when, where, and by whom a medicine is being used. It is a way of finding out the impact of a medicine as well as the usage results in a large, well-defined population. Also, it can help provide some indication as to how a particular drug is benefitting society and how it may be having a negative impact. Pharmacoepidemiology can be carried out both before and after a medicine is taken to market.
Pharmacoepidemiology takes into consideration disciplines such as biostatistics, computer programming, epidemiology, administrative data, medicine, and pharmacology.
Public health bodies, both national and global, are involved in pharmacoepidemiology. These health bodies include the World Health Organization (WHO), private sector organizations, and drug companies.
Pharmacovigilance, where the impact of a drug is monitored in populations using that particular product, is an integral aspect of pharmacoepidemiology. Organizations can track medicines for evidence of adverse events and safety issues as well as post-marketing activities. Similarly, having this long-term knowledge about a medicine and its impact can help scientists improve its use.
Pharmacoepidemiology came to the forefront in the 1960s when the use of antibiotics was being tracked in some European countries.
Also, pharmacoepidemiology was a useful tool when the thalidomide crisis occurred. Scientists noticed a rise in the percentage of abnormalities in infants born to women who were using thalidomide as a treatment for nausea. Pharmacoepidemiology was useful in this case for determining more information.
Pharmacoepidemiology uses clinical epidemiology to examine:
Researchers also need to be knowledgeable about the illness that the patients has to enable useful comparisons.
Another area that can be studied in depth is the profile of the doctors that are prescribing a type of medicine. Patterns in education, age, or gender may have an impact on how or what they prescribe.
Other aspects that may influence the use of specific medicines are the location of the doctor or whether the medic is more prone to being an early adopter for new medicines.
Post-marketing monitoring of a drug can help scientists discover the efficacy of the medicine as well as its toxicity. Cases of adverse events can be better tracked in the population through the use of pharmacoepidemiology.
Scientists can learn:
To generate an awareness of a drug’s efficacy, heterogeneous groups of patients that share a similar age, gender, and comorbidities must be analyzed.
Researchers also have the opportunity to study the outcomes of a medicine in comparison to others on the market for the same disease. Examining a drug’s use in the population can also reveal whether doctors are using the medicine for off-label treatments. With pharmacoepidemiology, scientists may also be able to deduce the impact of an overdose.
In addition to the health impact of a certain drug, economic details can be calculated for health bodies or governments. They can work out the cost per treatment day or the cost in relation to the patient’s income.